EVI5L-VAV1 Fusion FISH Probe
The EVI5L-VAV1 Fusion FISH Probe is used to confirm a fusion of the EVI5L and VAV1 genes. The fusion of the EVI5L and VAV1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EVI5L-VAV1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-RERE | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-REOR | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-REGO | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-REGR | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-REAQ | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-ORRE | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-OROR | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-ORGO | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-ORAQ | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-GORE | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-GOOR | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-GOGO | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-GOGR | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-GOAQ | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-GRRE | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-GROR | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-GRGO | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-GRGR | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-GRAQ | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-AQRE | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-AQOR | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-AQGO | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-AQGR | 20 (40 μL) | 200 μL |
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| EVI5L-VAV1-20-AQAQ | 20 (40 μL) | 200 μL |
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VAV1 Gene Summary
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
Gene Name: Vav Guanine Nucleotide Exchange Factor 1
Chromosome: CHR19: 6772721 -6857371
Locus: 19p13.3
EVI5L Gene Summary
The Ecotropic Viral Integration Site 5 Like (EVI5L) gene is located on chr19 :7895160-7929862 at 19p13.2.
Gene Name: Ecotropic Viral Integration Site 5 Like
Chromosome: CHR19: 7895160 -7929862
Locus: 19p13.2
Gene Diseases
The EVI5L VAV1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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