ETV6-PDE6H Fusion FISH Probe
The ETV6-PDE6H Fusion FISH Probe is used to confirm a fusion of the ETV6 and PDE6H genes. The fusion of the ETV6 and PDE6H genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ETV6-PDE6H-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-RERE | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-REOR | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-REGO | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-REGR | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-REAQ | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-ORRE | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-OROR | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-ORGO | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-ORAQ | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-GORE | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-GOOR | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-GOGO | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-GOGR | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-GOAQ | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-GRRE | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-GROR | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-GRGO | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-GRGR | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-GRAQ | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-AQRE | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-AQOR | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-AQGO | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-AQGR | 20 (40 μL) | 200 μL |
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| ETV6-PDE6H-20-AQAQ | 20 (40 μL) | 200 μL |
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ETV6 Gene Summary
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008]
Gene Name: ETS Variant 6
Chromosome: CHR12: 11802787 -12048325
Locus: 12p13.2
PDE6H Gene Summary
This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A). [provided by RefSeq, Mar 2010]
Gene Name: Phosphodiesterase 6H
Chromosome: CHR12: 15125955 -15134799
Locus: 12p12.3
Gene Diseases
The ETV6 PDE6H Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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