ETV1-CACNA2D1 Fusion FISH Probe
The ETV1-CACNA2D1 Fusion FISH Probe is used to confirm a fusion of the ETV1 and CACNA2D1 genes. The fusion of the ETV1 and CACNA2D1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ETV1-CACNA2D1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-RERE | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-REOR | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-REGO | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-REGR | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-REAQ | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-ORRE | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-OROR | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-ORGO | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-GORE | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-GOOR | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-GOGO | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-GOGR | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-GRRE | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-GROR | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-GRGO | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-GRGR | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-AQRE | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-AQOR | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-AQGO | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-AQGR | 20 (40 μL) | 200 μL |
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| ETV1-CACNA2D1-20-AQAQ | 20 (40 μL) | 200 μL |
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CACNA2D1 Gene Summary
The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]
Gene Name: Calcium Voltage-gated Channel Auxiliary Subunit Alpha2delta 1
Chromosome: CHR7: 81579417 -82073031
Locus: 7q21.11
ETV1 Gene Summary
This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016]
Gene Name: ETS Variant 1
Chromosome: CHR7: 13930855 -14031050
Locus: 7p21.2
Gene Diseases
The ETV1 CACNA2D1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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