ETHE1-PLAUR Fusion FISH Probe
The ETHE1-PLAUR Fusion FISH Probe is used to confirm a fusion of the ETHE1 and PLAUR genes. The fusion of the ETHE1 and PLAUR genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ETHE1-PLAUR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-RERE | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-REOR | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-REGO | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-REGR | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-REAQ | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-ORRE | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-OROR | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-ORGO | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-ORAQ | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-GORE | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-GOOR | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-GOGO | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-GOGR | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-GOAQ | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-GRRE | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-GROR | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-GRGO | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-GRGR | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-GRAQ | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-AQRE | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-AQOR | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-AQGO | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-AQGR | 20 (40 μL) | 200 μL |
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| ETHE1-PLAUR-20-AQAQ | 20 (40 μL) | 200 μL |
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PLAUR Gene Summary
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]
Gene Name: Plasminogen Activator, Urokinase Receptor
Chromosome: CHR19: 44150246 -44174498
Locus: 19q13.31
ETHE1 Gene Summary
This gene encodes a member of the metallo beta-lactamase family of iron-containing proteins involved in the mitochondrial sulfide oxidation pathway. The encoded protein catalyzes the oxidation of a persulfide substrate to sulfite. Certain mutations in this gene cause ethylmalonic encephalopathy, an infantile metabolic disorder affecting the brain, gastrointestinal tract and peripheral vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Gene Name: ETHE1, Persulfide Dioxygenase
Chromosome: CHR19: 44010870 -44031396
Locus: 19q13.31
Gene Diseases
The ETHE1 PLAUR Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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