ESRRA-KCNK4 Fusion FISH Probe
The ESRRA-KCNK4 Fusion FISH Probe is used to confirm a fusion of the ESRRA and KCNK4 genes. The fusion of the ESRRA and KCNK4 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ESRRA-KCNK4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-RERE | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-REOR | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-REGO | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-REGR | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-REAQ | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-ORRE | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-OROR | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-ORGO | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-ORAQ | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-GORE | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-GOOR | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-GOGO | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-GOGR | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-GOAQ | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-GRRE | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-GROR | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-GRGO | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-GRGR | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-GRAQ | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-AQRE | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-AQOR | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-AQGO | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-AQGR | 20 (40 μL) | 200 μL |
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| ESRRA-KCNK4-20-AQAQ | 20 (40 μL) | 200 μL |
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ESRRA Gene Summary
The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Name: Estrogen Related Receptor Alpha
Chromosome: CHR11: 64073043 -64084210
Locus: 11q13.1
KCNK4 Gene Summary
This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015]
Gene Name: Potassium Two Pore Domain Channel Subfamily K Member 4
Chromosome: CHR11: 64058792 -64067503
Locus: 11q13.1
Gene Diseases
The ESRRA KCNK4 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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