ESR1-TFB1M Fusion FISH Probe
The ESR1-TFB1M Fusion FISH Probe is used to confirm a fusion of the ESR1 and TFB1M genes. The fusion of the ESR1 and TFB1M genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ESR1-TFB1M-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-RERE | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-REOR | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-REGO | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-REGR | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-REAQ | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-ORRE | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-OROR | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-ORGO | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-ORAQ | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-GORE | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-GOOR | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-GOGO | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-GOGR | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-GOAQ | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-GRRE | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-GROR | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-GRGO | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-GRGR | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-GRAQ | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-AQRE | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-AQOR | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-AQGO | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-AQGR | 20 (40 μL) | 200 μL |
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| ESR1-TFB1M-20-AQAQ | 20 (40 μL) | 200 μL |
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ESR1 Gene Summary
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
Gene Name: Estrogen Receptor 1
Chromosome: CHR6: 152011630 -152424408
Locus: 6q25.1-q25.2
TFB1M Gene Summary
The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).[provided by RefSeq, Aug 2010]
Gene Name: Transcription Factor B1, Mitochondrial
Chromosome: CHR6: 155577263 -155635617
Locus: 6q25.3
Gene Diseases
The ESR1 TFB1M Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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