ESR1-PDE7B Fusion FISH Probe
The ESR1-PDE7B Fusion FISH Probe is used to confirm a fusion of the ESR1 and PDE7B genes. The fusion of the ESR1 and PDE7B genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ESR1-PDE7B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-RERE | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-REOR | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-REGO | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-REGR | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-REAQ | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-ORRE | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-OROR | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-ORGO | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-ORAQ | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-GORE | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-GOOR | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-GOGO | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-GOGR | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-GOAQ | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-GRRE | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-GROR | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-GRGO | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-GRGR | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-GRAQ | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-AQRE | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-AQOR | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-AQGO | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-AQGR | 20 (40 μL) | 200 μL |
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| ESR1-PDE7B-20-AQAQ | 20 (40 μL) | 200 μL |
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ESR1 Gene Summary
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
Gene Name: Estrogen Receptor 1
Chromosome: CHR6: 152011630 -152424408
Locus: 6q25.1-q25.2
PDE7B Gene Summary
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.[provided by RefSeq, Apr 2009]
Gene Name: Phosphodiesterase 7B
Chromosome: CHR6: 136172833 -136516709
Locus: 6q23.3
Gene Diseases
The ESR1 PDE7B Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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