ERLIN1-DOCK1 Fusion FISH Probe
The ERLIN1-DOCK1 Fusion FISH Probe is used to confirm a fusion of the ERLIN1 and DOCK1 genes. The fusion of the ERLIN1 and DOCK1 genes has been associated with Lymphoid Neoplasm Diffuse Large B-cell Lymphoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ERLIN1-DOCK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-RERE | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-REOR | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-REGO | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-REGR | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-REAQ | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-ORRE | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-OROR | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-ORGO | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-GORE | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-GOOR | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-GOGO | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-GOGR | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-GRRE | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-GROR | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-GRGO | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-GRGR | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-AQRE | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-AQOR | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-AQGO | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-AQGR | 20 (40 μL) | 200 μL |
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| ERLIN1-DOCK1-20-AQAQ | 20 (40 μL) | 200 μL |
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DOCK1 Gene Summary
This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Name: Dedicator Of Cytokinesis 1
Chromosome: CHR10: 128594022 -129250780
Locus: 10q26.2
ERLIN1 Gene Summary
The protein encoded by this gene is part of a protein complex that mediates degradation of inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum. The encoded protein also binds cholesterol and regulates the SREBP signaling pathway, which promotes cellular cholesterol homeostasis. Defects in this gene have been associated with spastic paraplegia 62. [provided by RefSeq, Dec 2016]
Gene Name: ER Lipid Raft Associated 1
Chromosome: CHR10: 101909846 -101945814
Locus: 10q24.31
Gene Diseases
The ERLIN1 DOCK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lymphoid Neoplasm Diffuse Large B-cell Lymphoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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