ERG-TMPRSS2 Fusion FISH Probe
The ERG-TMPRSS2 Fusion FISH Probe is used to confirm a fusion of the ERG and TMPRSS2 genes. The fusion of the ERG and TMPRSS2 genes has been associated with Prostate Adenocarcinoma, and Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ERG-TMPRSS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-RERE | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-REOR | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-REGO | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-REGR | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-REAQ | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-ORRE | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-OROR | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-ORGO | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-GORE | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-GOOR | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-GOGO | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-GOGR | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-GRRE | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-GROR | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-GRGO | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-GRGR | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-AQRE | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-AQOR | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-AQGO | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-AQGR | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-AQAQ | 20 (40 μL) | 200 μL |
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ERG Gene Summary
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]
Gene Name: ERG, ETS Transcription Factor
Chromosome: CHR21: 39739182 -40033618
Locus: 21q22.2
TMPRSS2 Gene Summary
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Name: Transmembrane Protease, Serine 2
Chromosome: CHR21: 42836477 -42880085
Locus: 21q22.3
Gene Diseases
The ERG TMPRSS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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