ERG-TAF8 Fusion FISH Probe
The ERG-TAF8 Fusion FISH Probe is used to confirm a fusion of the ERG and TAF8 genes. The fusion of the ERG and TAF8 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ERG-TAF8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-RERE | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-REOR | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-REGO | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-REGR | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-REAQ | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-ORRE | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-OROR | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-ORGO | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-ORAQ | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-GORE | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-GOOR | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-GOGO | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-GOGR | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-GOAQ | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-GRRE | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-GROR | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-GRGO | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-GRGR | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-GRAQ | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-AQRE | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-AQOR | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-AQGO | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-AQGR | 20 (40 μL) | 200 μL |
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| ERG-TAF8-20-AQAQ | 20 (40 μL) | 200 μL |
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ERG Gene Summary
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]
Gene Name: ERG, ETS Transcription Factor
Chromosome: CHR21: 39739182 -40033618
Locus: 21q22.2
TAF8 Gene Summary
This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: TATA-box Binding Protein Associated Factor 8
Chromosome: CHR6: 42018250 -42048644
Locus: 6p21.1
Gene Diseases
The ERG TAF8 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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