EPS8-PIK3C2G Fusion FISH Probe
The EPS8-PIK3C2G Fusion FISH Probe is used to confirm a fusion of the EPS8 and PIK3C2G genes. The fusion of the EPS8 and PIK3C2G genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EPS8-PIK3C2G-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-RERE | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-REOR | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-REGO | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-REGR | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-REAQ | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-ORRE | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-OROR | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-ORGO | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-ORAQ | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-GORE | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-GOOR | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-GOGO | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-GOGR | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-GOAQ | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-GRRE | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-GROR | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-GRGO | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-GRGR | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-GRAQ | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-AQRE | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-AQOR | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-AQGO | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-AQGR | 20 (40 μL) | 200 μL |
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| EPS8-PIK3C2G-20-AQAQ | 20 (40 μL) | 200 μL |
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EPS8 Gene Summary
This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Name: Epidermal Growth Factor Receptor Pathway Substrate 8
Chromosome: CHR12: 15773074 -15942510
Locus: 12p12.3
PIK3C2G Gene Summary
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Name: Phosphatidylinositol-4-phosphate 3-kinase Catalytic Subunit Type 2 Gamma
Chromosome: CHR12: 18414473 -18801352
Locus: 12p12.3
Gene Diseases
The EPS8 PIK3C2G Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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