EPN1-U2AF2 Fusion FISH Probe
The EPN1-U2AF2 Fusion FISH Probe is used to confirm a fusion of the EPN1 and U2AF2 genes. The fusion of the EPN1 and U2AF2 genes has been associated with Lung Squamous Cell Carcinoma, and Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EPN1-U2AF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-RERE | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-REOR | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-REGO | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-REGR | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-REAQ | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-ORRE | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-OROR | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-ORGO | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-GORE | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-GOOR | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-GOGO | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-GOGR | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-GRRE | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-GROR | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-GRGO | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-GRGR | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-AQRE | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-AQOR | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-AQGO | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-AQGR | 20 (40 μL) | 200 μL |
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| EPN1-U2AF2-20-AQAQ | 20 (40 μL) | 200 μL |
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U2AF2 Gene Summary
U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]
Gene Name: U2 Small Nuclear RNA Auxiliary Factor 2
Chromosome: CHR19: 56165415 -56186082
Locus: 19q13.42
EPN1 Gene Summary
This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. [provided by RefSeq, Mar 2016]
Gene Name: Epsin 1
Chromosome: CHR19: 56186560 -56207133
Locus: 19q13.42
Gene Diseases
The EPN1 U2AF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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