EPC2-MBD5 Fusion FISH Probe
The EPC2-MBD5 Fusion FISH Probe is used to confirm a fusion of the EPC2 and MBD5 genes. The fusion of the EPC2 and MBD5 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EPC2-MBD5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-RERE | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-REOR | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-REGO | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-REGR | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-REAQ | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-ORRE | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-OROR | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-ORGO | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-ORAQ | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-GORE | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-GOOR | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-GOGO | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-GOGR | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-GOAQ | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-GRRE | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-GROR | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-GRGO | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-GRGR | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-GRAQ | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-AQRE | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-AQOR | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-AQGO | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-AQGR | 20 (40 μL) | 200 μL |
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| EPC2-MBD5-20-AQAQ | 20 (40 μL) | 200 μL |
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EPC2 Gene Summary
The Enhancer Of Polycomb Homolog 2 (EPC2) gene is located on chr2 :149402559-149545136 at 2q23.1.
Gene Name: Enhancer Of Polycomb Homolog 2
Chromosome: CHR2: 149402559 -149545136
Locus: 2q23.1
MBD5 Gene Summary
This gene encodes a member of the methyl-CpG-binding domain (MBD) family. The MBD consists of about 70 residues and is the minimal region required for a methyl-CpG-binding protein binding specifically to methylated DNA. In addition to the MBD domain, this protein contains a PWWP domain (Pro-Trp-Trp-Pro motif), which consists of 100-150 amino acids and is found in numerous proteins that are involved in cell division, growth and differentiation. Mutations in this gene cause an autosomal dominant type of cognitive disability. The encoded protein interacts with the polycomb repressive complex PR-DUB which catalyzes the deubiquitination of a lysine residue of histone 2A. Haploinsufficiency of this gene is associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures. Alternatively spliced transcript variants have been found, but their full-length nature is not determined. [provided by RefSeq, Jul 2017]
Gene Name: Methyl-CpG Binding Domain Protein 5
Chromosome: CHR2: 148778579 -149271044
Locus: 2q23.1
Gene Diseases
The EPC2 MBD5 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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