EP300-RBX1 Fusion FISH Probe
The EP300-RBX1 Fusion FISH Probe is used to confirm a fusion of the EP300 and RBX1 genes. The fusion of the EP300 and RBX1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EP300-RBX1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-RERE | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-REOR | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-REGO | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-REGR | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-REAQ | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-ORRE | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-OROR | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-ORGO | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-ORAQ | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-GORE | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-GOOR | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-GOGO | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-GOGR | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-GOAQ | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-GRRE | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-GROR | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-GRGO | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-GRGR | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-GRAQ | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-AQRE | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-AQOR | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-AQGO | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-AQGR | 20 (40 μL) | 200 μL |
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| EP300-RBX1-20-AQAQ | 20 (40 μL) | 200 μL |
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EP300 Gene Summary
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
Gene Name: E1A Binding Protein P300
Chromosome: CHR22: 41488613 -41576081
Locus: 22q13.2
RBX1 Gene Summary
This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010]
Gene Name: Ring-box 1
Chromosome: CHR22: 41347350 -41369019
Locus: 22q13.2
Gene Diseases
The EP300 RBX1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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