ENTPD7-IDE Fusion FISH Probe
The ENTPD7-IDE Fusion FISH Probe is used to confirm a fusion of the ENTPD7 and IDE genes. The fusion of the ENTPD7 and IDE genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ENTPD7-IDE-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-RERE | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-REOR | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-REGO | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-REGR | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-REAQ | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-ORRE | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-OROR | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-ORGO | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-ORAQ | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-GORE | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-GOOR | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-GOGO | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-GOGR | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-GOAQ | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-GRRE | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-GROR | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-GRGO | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-GRGR | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-GRAQ | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-AQRE | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-AQOR | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-AQGO | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-AQGR | 20 (40 μL) | 200 μL |
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| ENTPD7-IDE-20-AQAQ | 20 (40 μL) | 200 μL |
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IDE Gene Summary
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]
Gene Name: Insulin Degrading Enzyme
Chromosome: CHR10: 94211440 -94333852
Locus: 10q23.33
ENTPD7 Gene Summary
This gene encodes a purine-converting ectoenzyme which belongs to the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. The encoded protein hydrolyzes extracellular nucleoside triphosphates (UTP, GTP, and CTP) to nucleoside monophosphates as part of a purinergic signaling pathway. It contains two transmembrane domains at the N- and C-termini and a large, hydrophobic catalytic domain located in between. This gene affects oxidative stress as well as DNA damage and is a mediator of senescence. [provided by RefSeq, Mar 2017]
Gene Name: Ectonucleoside Triphosphate Diphosphohydrolase 7
Chromosome: CHR10: 101419262 -101471002
Locus: 10q24.2
Gene Diseases
The ENTPD7 IDE Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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