EML6-SPTBN1 Fusion FISH Probe
The EML6-SPTBN1 Fusion FISH Probe is used to confirm a fusion of the EML6 and SPTBN1 genes. The fusion of the EML6 and SPTBN1 genes has been associated with Pheochromocytoma And Paraganglioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EML6-SPTBN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-RERE | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-REOR | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-REGO | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-REGR | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-REAQ | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-ORRE | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-OROR | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-ORGO | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-GORE | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-GOOR | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-GOGO | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-GOGR | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-GRRE | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-GROR | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-GRGO | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-GRGR | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-AQRE | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-AQOR | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-AQGO | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-AQGR | 20 (40 μL) | 200 μL |
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| EML6-SPTBN1-20-AQAQ | 20 (40 μL) | 200 μL |
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SPTBN1 Gene Summary
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Spectrin Beta, Non-erythrocytic 1
Chromosome: CHR2: 54683453 -54898583
Locus: 2p16.2
EML6 Gene Summary
The Echinoderm Microtubule Associated Protein Like 6 (EML6) gene is located on chr2 :54952148-55199156 at 2p16.1.
Gene Name: Echinoderm Microtubule Associated Protein Like 6
Chromosome: CHR2: 54952148 -55199156
Locus: 2p16.1
Gene Diseases
The EML6 SPTBN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Pheochromocytoma And Paraganglioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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