EML4-COX7A2L Fusion FISH Probe
The EML4-COX7A2L Fusion FISH Probe is used to confirm a fusion of the EML4 and COX7A2L genes. The fusion of the EML4 and COX7A2L genes has been associated with Lung Squamous Cell Carcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EML4-COX7A2L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-RERE | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-REOR | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-REGO | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-REGR | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-REAQ | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-ORRE | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-OROR | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-ORGO | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-ORAQ | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-GORE | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-GOOR | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-GOGO | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-GOGR | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-GOAQ | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-GRRE | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-GROR | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-GRGO | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-GRGR | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-GRAQ | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-AQRE | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-AQOR | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-AQGO | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-AQGR | 20 (40 μL) | 200 μL |
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| EML4-COX7A2L-20-AQAQ | 20 (40 μL) | 200 μL |
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COX7A2L Gene Summary
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]
Gene Name: Cytochrome C Oxidase Subunit 7A2 Like
Chromosome: CHR2: 42577644 -42588356
Locus: 2p21
EML4 Gene Summary
This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015]
Gene Name: Echinoderm Microtubule Associated Protein Like 4
Chromosome: CHR2: 42396489 -42559688
Locus: 2p21
Gene Diseases
The EML4 COX7A2L Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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