EML1-GPI Fusion FISH Probe
The EML1-GPI Fusion FISH Probe is used to confirm a fusion of the EML1 and GPI genes. The fusion of the EML1 and GPI genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EML1-GPI-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-RERE | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-REOR | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-REGO | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-REGR | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-REAQ | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-ORRE | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-OROR | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-ORGO | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-ORAQ | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-GORE | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-GOOR | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-GOGO | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-GOGR | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-GOAQ | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-GRRE | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-GROR | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-GRGO | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-GRGR | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-GRAQ | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-AQRE | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-AQOR | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-AQGO | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-AQGR | 20 (40 μL) | 200 μL |
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| EML1-GPI-20-AQAQ | 20 (40 μL) | 200 μL |
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EML1 Gene Summary
Human echinoderm microtubule-associated protein-like is a strong candidate for the Usher syndrome type 1A gene. Usher syndromes (USHs) are a group of genetic disorders consisting of congenital deafness, retinitis pigmentosa, and vestibular dysfunction of variable onset and severity depending on the genetic type. The disease process in USHs involves the entire brain and is not limited to the posterior fossa or auditory and visual systems. The USHs are catagorized as type I (USH1A, USH1B, USH1C, USH1D, USH1E and USH1F), type II (USH2A and USH2B) and type III (USH3). The type I is the most severe form. Gene loci responsible for these three types are all mapped. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Echinoderm Microtubule Associated Protein Like 1
Chromosome: CHR14: 100259744 -100408395
Locus: 14q32.2
GPI Gene Summary
This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Gene Name: Glucose-6-phosphate Isomerase
Chromosome: CHR19: 34855644 -34893318
Locus: 19q13.11
Gene Diseases
The EML1 GPI Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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