ELP4-CFTR Fusion FISH Probe
The ELP4-CFTR Fusion FISH Probe is used to confirm a fusion of the ELP4 and CFTR genes. The fusion of the ELP4 and CFTR genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ELP4-CFTR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-RERE | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-REOR | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-REGO | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-REGR | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-REAQ | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-ORRE | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-OROR | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-ORGO | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-ORAQ | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-GORE | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-GOOR | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-GOGO | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-GOGR | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-GOAQ | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-GRRE | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-GROR | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-GRGO | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-GRGR | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-GRAQ | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-AQRE | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-AQOR | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-AQGO | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-AQGR | 20 (40 μL) | 200 μL |
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| ELP4-CFTR-20-AQAQ | 20 (40 μL) | 200 μL |
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CFTR Gene Summary
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a chloride channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome. [provided by RefSeq, Aug 2017]
Gene Name: Cystic Fibrosis Transmembrane Conductance Regulator
Chromosome: CHR7: 117120016 -117308718
Locus: 7q31.2
ELP4 Gene Summary
This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants. This gene has also been associated with Rolandic epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Gene Name: Elongator Acetyltransferase Complex Subunit 4
Chromosome: CHR11: 31531296 -31805329
Locus: 11p13
Gene Diseases
The ELP4 CFTR Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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