ELN-METTL2B Fusion FISH Probe
The ELN-METTL2B Fusion FISH Probe is used to confirm a fusion of the ELN and METTL2B genes. The fusion of the ELN and METTL2B genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ELN-METTL2B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-RERE | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-REOR | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-REGO | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-REGR | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-REAQ | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-ORRE | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-OROR | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-ORGO | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-ORAQ | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-GORE | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-GOOR | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-GOGO | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-GOGR | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-GOAQ | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-GRRE | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-GROR | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-GRGO | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-GRGR | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-GRAQ | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-AQRE | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-AQOR | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-AQGO | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-AQGR | 20 (40 μL) | 200 μL |
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| ELN-METTL2B-20-AQAQ | 20 (40 μL) | 200 μL |
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ELN Gene Summary
This gene encodes a protein that is one of the two components of elastic fibers. Elastic fibers comprise part of the extracellular matrix and confer elasticity to organs and tissues including the heart, skin, lungs, ligaments, and blood vessels. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Degradation products of the encoded protein, known as elastin-derived peptides or elastokines, bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. [provided by RefSeq, Aug 2017]
Gene Name: Elastin
Chromosome: CHR7: 73442426 -73484236
Locus: 7q11.23
METTL2B Gene Summary
This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Gene Name: Methyltransferase Like 2B
Chromosome: CHR7: 128116782 -128142978
Locus: 7q32.1
Gene Diseases
The ELN METTL2B Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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