ELK3-PTPRR Fusion FISH Probe
The ELK3-PTPRR Fusion FISH Probe is used to confirm a fusion of the ELK3 and PTPRR genes. The fusion of the ELK3 and PTPRR genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ELK3-PTPRR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-RERE | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-REOR | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-REGO | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-REGR | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-REAQ | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-ORRE | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-OROR | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-ORGO | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-ORAQ | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-GORE | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-GOOR | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-GOGO | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-GOGR | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-GOAQ | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-GRRE | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-GROR | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-GRGO | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-GRGR | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-GRAQ | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-AQRE | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-AQOR | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-AQGO | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-AQGR | 20 (40 μL) | 200 μL |
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| ELK3-PTPRR-20-AQAQ | 20 (40 μL) | 200 μL |
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ELK3 Gene Summary
This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Gene Name: ELK3, ETS Transcription Factor
Chromosome: CHR12: 96588206 -96661606
Locus: 12q23.1
PTPRR Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type R
Chromosome: CHR12: 71031852 -71314584
Locus: 12q15
Gene Diseases
The ELK3 PTPRR Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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