ELF5-CAT Fusion FISH Probe
The ELF5-CAT Fusion FISH Probe is used to confirm a fusion of the ELF5 and CAT genes. The fusion of the ELF5 and CAT genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ELF5-CAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-RERE | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-REOR | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-REGO | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-REGR | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-REAQ | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-ORRE | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-OROR | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-ORGO | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-GORE | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-GOOR | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-GOGO | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-GOGR | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-GRRE | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-GROR | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-GRGO | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-GRGR | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-AQRE | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-AQOR | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-AQGO | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-AQGR | 20 (40 μL) | 200 μL |
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| ELF5-CAT-20-AQAQ | 20 (40 μL) | 200 μL |
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CAT Gene Summary
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
Gene Name: Catalase
Chromosome: CHR11: 34460471 -34493607
Locus: 11p13
ELF5 Gene Summary
The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Gene Name: E74 Like ETS Transcription Factor 5
Chromosome: CHR11: 34500341 -34535347
Locus: 11p13
Gene Diseases
The ELF5 CAT Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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