ELAC2-COX10 Fusion FISH Probe
The ELAC2-COX10 Fusion FISH Probe is used to confirm a fusion of the ELAC2 and COX10 genes. The fusion of the ELAC2 and COX10 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ELAC2-COX10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-RERE | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-REOR | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-REGO | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-REGR | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-REAQ | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-ORRE | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-OROR | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-ORGO | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-ORAQ | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-GORE | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-GOOR | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-GOGO | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-GOGR | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-GOAQ | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-GRRE | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-GROR | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-GRGO | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-GRGR | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-GRAQ | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-AQRE | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-AQOR | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-AQGO | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-AQGR | 20 (40 μL) | 200 μL |
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| ELAC2-COX10-20-AQAQ | 20 (40 μL) | 200 μL |
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COX10 Gene Summary
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. [provided by RefSeq, Jul 2008]
Gene Name: COX10, Heme A:farnesyltransferase Cytochrome C Oxidase Assembly Factor
Chromosome: CHR17: 13972718 -14111996
Locus: 17p12
ELAC2 Gene Summary
The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Name: ElaC Ribonuclease Z 2
Chromosome: CHR17: 12894928 -12921381
Locus: 17p12
Gene Diseases
The ELAC2 COX10 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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