EIF5-NOTCH2 Fusion FISH Probe
The EIF5-NOTCH2 Fusion FISH Probe is used to confirm a fusion of the EIF5 and NOTCH2 genes. The fusion of the EIF5 and NOTCH2 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EIF5-NOTCH2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-RERE | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-REOR | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-REGO | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-REGR | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-REAQ | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-ORRE | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-OROR | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-ORGO | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-ORAQ | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-GORE | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-GOOR | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-GOGO | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-GOGR | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-GOAQ | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-GRRE | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-GROR | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-GRGO | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-GRGR | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-GRAQ | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-AQRE | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-AQOR | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-AQGO | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-AQGR | 20 (40 μL) | 200 μL |
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| EIF5-NOTCH2-20-AQAQ | 20 (40 μL) | 200 μL |
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EIF5 Gene Summary
Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010]
Gene Name: Eukaryotic Translation Initiation Factor 5
Chromosome: CHR14: 103800492 -103811361
Locus: 14q32.32
NOTCH2 Gene Summary
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Gene Name: Notch 2
Chromosome: CHR1: 120454175 -120612317
Locus: 1p12
Gene Diseases
The EIF5 NOTCH2 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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