EIF4H-ELN Fusion FISH Probe
The EIF4H-ELN Fusion FISH Probe is used to confirm a fusion of the EIF4H and ELN genes. The fusion of the EIF4H and ELN genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EIF4H-ELN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-RERE | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-REOR | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-REGO | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-REGR | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-REAQ | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-ORRE | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-OROR | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-ORGO | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-ORAQ | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-GORE | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-GOOR | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-GOGO | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-GOGR | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-GOAQ | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-GRRE | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-GROR | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-GRGO | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-GRGR | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-GRAQ | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-AQRE | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-AQOR | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-AQGO | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-AQGR | 20 (40 μL) | 200 μL |
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| EIF4H-ELN-20-AQAQ | 20 (40 μL) | 200 μL |
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ELN Gene Summary
This gene encodes a protein that is one of the two components of elastic fibers. Elastic fibers comprise part of the extracellular matrix and confer elasticity to organs and tissues including the heart, skin, lungs, ligaments, and blood vessels. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Degradation products of the encoded protein, known as elastin-derived peptides or elastokines, bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. [provided by RefSeq, Aug 2017]
Gene Name: Elastin
Chromosome: CHR7: 73442426 -73484236
Locus: 7q11.23
EIF4H Gene Summary
This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Gene Name: Eukaryotic Translation Initiation Factor 4H
Chromosome: CHR7: 73588705 -73611429
Locus: 7q11.23
Gene Diseases
The EIF4H ELN Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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