EIF4G3-RAP1GAP Fusion FISH Probe
The EIF4G3-RAP1GAP Fusion FISH Probe is used to confirm a fusion of the EIF4G3 and RAP1GAP genes. The fusion of the EIF4G3 and RAP1GAP genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EIF4G3-RAP1GAP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-RERE | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-REOR | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-REGO | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-REGR | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-REAQ | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-ORRE | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-OROR | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-ORGO | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-ORAQ | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-GORE | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-GOOR | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-GOGO | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-GOGR | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-GOAQ | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-GRRE | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-GROR | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-GRGO | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-GRGR | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-GRAQ | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-AQRE | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-AQOR | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-AQGO | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-AQGR | 20 (40 μL) | 200 μL |
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| EIF4G3-RAP1GAP-20-AQAQ | 20 (40 μL) | 200 μL |
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RAP1GAP Gene Summary
This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]
Gene Name: RAP1 GTPase Activating Protein
Chromosome: CHR1: 21922707 -21995856
Locus: 1p36.12
EIF4G3 Gene Summary
The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]
Gene Name: Eukaryotic Translation Initiation Factor 4 Gamma 3
Chromosome: CHR1: 21132784 -21503381
Locus: 1p36.12
Gene Diseases
The EIF4G3 RAP1GAP Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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