EIF4G3-PPP2R3A Fusion FISH Probe
The EIF4G3-PPP2R3A Fusion FISH Probe is used to confirm a fusion of the EIF4G3 and PPP2R3A genes. The fusion of the EIF4G3 and PPP2R3A genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EIF4G3-PPP2R3A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-RERE | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-REOR | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-REGO | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-REGR | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-REAQ | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-ORRE | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-OROR | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-ORGO | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-ORAQ | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-GORE | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-GOOR | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-GOGO | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-GOGR | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-GOAQ | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-GRRE | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-GROR | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-GRGO | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-GRGR | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-GRAQ | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-AQRE | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-AQOR | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-AQGO | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-AQGR | 20 (40 μL) | 200 μL |
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| EIF4G3-PPP2R3A-20-AQAQ | 20 (40 μL) | 200 μL |
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PPP2R3A Gene Summary
This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]
Gene Name: Protein Phosphatase 2 Regulatory Subunit B''alpha
Chromosome: CHR3: 135684514 -135866752
Locus: 3q22.2-q22.3
EIF4G3 Gene Summary
The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]
Gene Name: Eukaryotic Translation Initiation Factor 4 Gamma 3
Chromosome: CHR1: 21132784 -21503381
Locus: 1p36.12
Gene Diseases
The EIF4G3 PPP2R3A Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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