EIF4G3-LIN28A Fusion FISH Probe
The EIF4G3-LIN28A Fusion FISH Probe is used to confirm a fusion of the EIF4G3 and LIN28A genes. The fusion of the EIF4G3 and LIN28A genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EIF4G3-LIN28A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-RERE | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-REOR | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-REGO | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-REGR | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-REAQ | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-ORRE | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-OROR | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-ORGO | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-ORAQ | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-GORE | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-GOOR | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-GOGO | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-GOGR | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-GOAQ | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-GRRE | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-GROR | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-GRGO | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-GRGR | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-GRAQ | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-AQRE | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-AQOR | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-AQGO | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-AQGR | 20 (40 μL) | 200 μL |
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| EIF4G3-LIN28A-20-AQAQ | 20 (40 μL) | 200 μL |
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EIF4G3 Gene Summary
The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]
Gene Name: Eukaryotic Translation Initiation Factor 4 Gamma 3
Chromosome: CHR1: 21132784 -21503381
Locus: 1p36.12
LIN28A Gene Summary
This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015]
Gene Name: Lin-28 Homolog A
Chromosome: CHR1: 26737268 -26756219
Locus: 1p36.11
Gene Diseases
The EIF4G3 LIN28A Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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