EIF4G3-LAMC1 Fusion FISH Probe
The EIF4G3-LAMC1 Fusion FISH Probe is used to confirm a fusion of the EIF4G3 and LAMC1 genes. The fusion of the EIF4G3 and LAMC1 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EIF4G3-LAMC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-RERE | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-REOR | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-REGO | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-REGR | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-REAQ | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-ORRE | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-OROR | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-ORGO | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-GORE | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-GOOR | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-GOGO | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-GOGR | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-GRRE | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-GROR | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-GRGO | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-GRGR | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-AQRE | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-AQOR | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-AQGO | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-AQGR | 20 (40 μL) | 200 μL |
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| EIF4G3-LAMC1-20-AQAQ | 20 (40 μL) | 200 μL |
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LAMC1 Gene Summary
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis. [provided by RefSeq, Aug 2011]
Gene Name: Laminin Subunit Gamma 1
Chromosome: CHR1: 182992594 -183114727
Locus: 1q25.3
EIF4G3 Gene Summary
The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]
Gene Name: Eukaryotic Translation Initiation Factor 4 Gamma 3
Chromosome: CHR1: 21132784 -21503381
Locus: 1p36.12
Gene Diseases
The EIF4G3 LAMC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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