EIF4G2-UTRN Fusion FISH Probe
The EIF4G2-UTRN Fusion FISH Probe is used to confirm a fusion of the EIF4G2 and UTRN genes. The fusion of the EIF4G2 and UTRN genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EIF4G2-UTRN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-RERE | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-REOR | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-REGO | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-REGR | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-REAQ | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-ORRE | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-OROR | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-ORGO | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-ORAQ | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-GORE | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-GOOR | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-GOGO | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-GOGR | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-GOAQ | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-GRRE | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-GROR | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-GRGO | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-GRGR | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-GRAQ | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-AQRE | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-AQOR | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-AQGO | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-AQGR | 20 (40 μL) | 200 μL |
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| EIF4G2-UTRN-20-AQAQ | 20 (40 μL) | 200 μL |
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EIF4G2 Gene Summary
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
Gene Name: Eukaryotic Translation Initiation Factor 4 Gamma 2
Chromosome: CHR11: 10818592 -10830582
Locus: 11p15.4
UTRN Gene Summary
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Name: Utrophin
Chromosome: CHR6: 144612872 -145174170
Locus: 6q24.2
Gene Diseases
The EIF4G2 UTRN Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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