EIF4G2-ERBB3 Fusion FISH Probe
The EIF4G2-ERBB3 Fusion FISH Probe is used to confirm a fusion of the EIF4G2 and ERBB3 genes. The fusion of the EIF4G2 and ERBB3 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EIF4G2-ERBB3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-RERE | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-REOR | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-REGO | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-REGR | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-REAQ | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-ORRE | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-OROR | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-ORGO | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-ORAQ | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-GORE | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-GOOR | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-GOGO | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-GOGR | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-GOAQ | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-GRRE | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-GROR | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-GRGO | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-GRGR | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-GRAQ | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-AQRE | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-AQOR | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-AQGO | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-AQGR | 20 (40 μL) | 200 μL |
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| EIF4G2-ERBB3-20-AQAQ | 20 (40 μL) | 200 μL |
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EIF4G2 Gene Summary
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
Gene Name: Eukaryotic Translation Initiation Factor 4 Gamma 2
Chromosome: CHR11: 10818592 -10830582
Locus: 11p15.4
ERBB3 Gene Summary
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Name: Erb-b2 Receptor Tyrosine Kinase 3
Chromosome: CHR12: 56473808 -56497291
Locus: 12q13.2
Gene Diseases
The EIF4G2 ERBB3 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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