EIF4G2-EIF2AK2 Fusion FISH Probe
The EIF4G2-EIF2AK2 Fusion FISH Probe is used to confirm a fusion of the EIF4G2 and EIF2AK2 genes. The fusion of the EIF4G2 and EIF2AK2 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EIF4G2-EIF2AK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-RERE | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-REOR | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-REGO | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-REGR | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-REAQ | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-ORRE | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-OROR | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-ORGO | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-GORE | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-GOOR | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-GOGO | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-GOGR | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-GRRE | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-GROR | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-GRGO | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-GRGR | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-AQRE | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-AQOR | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-AQGO | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-AQGR | 20 (40 μL) | 200 μL |
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| EIF4G2-EIF2AK2-20-AQAQ | 20 (40 μL) | 200 μL |
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EIF4G2 Gene Summary
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
Gene Name: Eukaryotic Translation Initiation Factor 4 Gamma 2
Chromosome: CHR11: 10818592 -10830582
Locus: 11p15.4
EIF2AK2 Gene Summary
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2
Chromosome: CHR2: 37333698 -37384190
Locus: 2p22.2
Gene Diseases
The EIF4G2 EIF2AK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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