EIF4G1-SNW1 Fusion FISH Probe
The EIF4G1-SNW1 Fusion FISH Probe is used to confirm a fusion of the EIF4G1 and SNW1 genes. The fusion of the EIF4G1 and SNW1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EIF4G1-SNW1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-RERE | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-REOR | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-REGO | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-REGR | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-REAQ | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-ORRE | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-OROR | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-ORGO | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-ORAQ | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-GORE | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-GOOR | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-GOGO | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-GOGR | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-GOAQ | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-GRRE | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-GROR | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-GRGO | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-GRGR | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-GRAQ | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-AQRE | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-AQOR | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-AQGO | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-AQGR | 20 (40 μL) | 200 μL |
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| EIF4G1-SNW1-20-AQAQ | 20 (40 μL) | 200 μL |
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EIF4G1 Gene Summary
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
Gene Name: Eukaryotic Translation Initiation Factor 4 Gamma 1
Chromosome: CHR3: 184032282 -184053146
Locus: 3q27.1
SNW1 Gene Summary
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: SNW Domain Containing 1
Chromosome: CHR14: 78183943 -78227497
Locus: 14q24.3
Gene Diseases
The EIF4G1 SNW1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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