EIF4ENIF1-COMT Fusion FISH Probe
The EIF4ENIF1-COMT Fusion FISH Probe is used to confirm a fusion of the EIF4ENIF1 and COMT genes. The fusion of the EIF4ENIF1 and COMT genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EIF4ENIF1-COMT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-RERE | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-REOR | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-REGO | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-REGR | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-REAQ | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-ORRE | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-OROR | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-ORGO | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-ORAQ | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-GORE | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-GOOR | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-GOGO | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-GOGR | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-GOAQ | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-GRRE | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-GROR | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-GRGO | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-GRGR | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-GRAQ | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-AQRE | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-AQOR | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-AQGO | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-AQGR | 20 (40 μL) | 200 μL |
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| EIF4ENIF1-COMT-20-AQAQ | 20 (40 μL) | 200 μL |
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COMT Gene Summary
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
Gene Name: Catechol-O-methyltransferase
Chromosome: CHR22: 19929262 -19957498
Locus: 22q11.21
EIF4ENIF1 Gene Summary
The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Gene Name: Eukaryotic Translation Initiation Factor 4E Nuclear Import Factor 1
Chromosome: CHR22: 31835344 -31885874
Locus: 22q12.2
Gene Diseases
The EIF4ENIF1 COMT Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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