EIF4EBP1-ADAM18 Fusion FISH Probe
The EIF4EBP1-ADAM18 Fusion FISH Probe is used to confirm a fusion of the EIF4EBP1 and ADAM18 genes. The fusion of the EIF4EBP1 and ADAM18 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EIF4EBP1-ADAM18-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-RERE | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-REOR | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-REGO | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-REGR | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-REAQ | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-ORRE | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-OROR | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-ORGO | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-ORAQ | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-GORE | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-GOOR | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-GOGO | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-GOGR | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-GOAQ | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-GRRE | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-GROR | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-GRGO | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-GRGR | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-GRAQ | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-AQRE | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-AQOR | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-AQGO | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-AQGR | 20 (40 μL) | 200 μL |
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| EIF4EBP1-ADAM18-20-AQAQ | 20 (40 μL) | 200 μL |
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EIF4EBP1 Gene Summary
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
Gene Name: Eukaryotic Translation Initiation Factor 4E Binding Protein 1
Chromosome: CHR8: 37888019 -37917883
Locus: 8p11.23
ADAM18 Gene Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature sperm surface protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Gene Name: ADAM Metallopeptidase Domain 18
Chromosome: CHR8: 39442086 -39587583
Locus: 8p11.22
Gene Diseases
The EIF4EBP1 ADAM18 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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