EIF2S1-GPHN Fusion FISH Probe
The EIF2S1-GPHN Fusion FISH Probe is used to confirm a fusion of the EIF2S1 and GPHN genes. The fusion of the EIF2S1 and GPHN genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EIF2S1-GPHN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-RERE | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-REOR | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-REGO | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-REGR | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-REAQ | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-ORRE | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-OROR | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-ORGO | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-ORAQ | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-GORE | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-GOOR | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-GOGO | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-GOGR | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-GOAQ | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-GRRE | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-GROR | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-GRGO | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-GRGR | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-GRAQ | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-AQRE | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-AQOR | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-AQGO | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-AQGR | 20 (40 μL) | 200 μL |
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| EIF2S1-GPHN-20-AQAQ | 20 (40 μL) | 200 μL |
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EIF2S1 Gene Summary
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]
Gene Name: Eukaryotic Translation Initiation Factor 2 Subunit Alpha
Chromosome: CHR14: 67827033 -67853233
Locus: 14q23.3
GPHN Gene Summary
This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known. [provided by RefSeq, Jul 2008]
Gene Name: Gephyrin
Chromosome: CHR14: 66974124 -67648525
Locus: 14q23.3-q24.1
Gene Diseases
The EIF2S1 GPHN Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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