EIF2AK3-NBAS Fusion FISH Probe
The EIF2AK3-NBAS Fusion FISH Probe is used to confirm a fusion of the EIF2AK3 and NBAS genes. The fusion of the EIF2AK3 and NBAS genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EIF2AK3-NBAS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-RERE | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-REOR | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-REGO | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-REGR | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-REAQ | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-ORRE | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-OROR | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-ORGO | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-ORAQ | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-GORE | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-GOOR | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-GOGO | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-GOGR | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-GOAQ | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-GRRE | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-GROR | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-GRGO | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-GRGR | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-GRAQ | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-AQRE | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-AQOR | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-AQGO | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-AQGR | 20 (40 μL) | 200 μL |
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| EIF2AK3-NBAS-20-AQAQ | 20 (40 μL) | 200 μL |
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EIF2AK3 Gene Summary
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]
Gene Name: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3
Chromosome: CHR2: 88856258 -88927094
Locus: 2p11.2
NBAS Gene Summary
This gene encodes a protein with two leucine zipper domains, a ribosomal protein S14 signature domain and a Sec39 like domain. The protein is thought to be involved in Golgi-to-ER transport. Mutations in this gene are associated with short stature, optic nerve atrophy, and Pelger-Huet anomaly. [provided by RefSeq, Oct 2012]
Gene Name: Neuroblastoma Amplified Sequence
Chromosome: CHR2: 15307031 -15701454
Locus: 2p24.3
Gene Diseases
The EIF2AK3 NBAS Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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