EIF2AK2-CEBPZ Fusion FISH Probe
The EIF2AK2-CEBPZ Fusion FISH Probe is used to confirm a fusion of the EIF2AK2 and CEBPZ genes. The fusion of the EIF2AK2 and CEBPZ genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EIF2AK2-CEBPZ-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-RERE | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-REOR | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-REGO | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-REGR | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-REAQ | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-ORRE | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-OROR | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-ORGO | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-ORAQ | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-GORE | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-GOOR | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-GOGO | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-GOGR | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-GOAQ | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-GRRE | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-GROR | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-GRGO | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-GRGR | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-GRAQ | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-AQRE | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-AQOR | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-AQGO | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-AQGR | 20 (40 μL) | 200 μL |
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| EIF2AK2-CEBPZ-20-AQAQ | 20 (40 μL) | 200 μL |
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EIF2AK2 Gene Summary
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2
Chromosome: CHR2: 37333698 -37384190
Locus: 2p22.2
CEBPZ Gene Summary
This gene belongs to the CEBP family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. Methylation of the promoter of this gene or mutations within the gene may be correlated with occurance of acute myeloid leukemia (AML). [provided by RefSeq, Jun 2016]
Gene Name: CCAAT/enhancer Binding Protein Zeta
Chromosome: CHR2: 37428774 -37458740
Locus: 2p22.2
Gene Diseases
The EIF2AK2 CEBPZ Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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