EI24-FEZ1 Fusion FISH Probe
The EI24-FEZ1 Fusion FISH Probe is used to confirm a fusion of the EI24 and FEZ1 genes. The fusion of the EI24 and FEZ1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EI24-FEZ1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-RERE | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-REOR | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-REGO | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-REGR | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-REAQ | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-ORRE | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-OROR | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-ORGO | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-ORAQ | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-GORE | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-GOOR | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-GOGO | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-GOGR | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-GOAQ | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-GRRE | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-GROR | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-GRGO | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-GRGR | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-GRAQ | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-AQRE | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-AQOR | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-AQGO | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-AQGR | 20 (40 μL) | 200 μL |
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| EI24-FEZ1-20-AQAQ | 20 (40 μL) | 200 μL |
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EI24 Gene Summary
This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]
Gene Name: EI24, Autophagy Associated Transmembrane Protein
Chromosome: CHR11: 125439297 -125454575
Locus: 11q24.2
FEZ1 Gene Summary
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]
Gene Name: Fasciculation And Elongation Protein Zeta 1
Chromosome: CHR11: 125315640 -125366206
Locus: 11q24.2
Gene Diseases
The EI24 FEZ1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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