EHMT2-ATF6B Fusion FISH Probe
The EHMT2-ATF6B Fusion FISH Probe is used to confirm a fusion of the EHMT2 and ATF6B genes. The fusion of the EHMT2 and ATF6B genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EHMT2-ATF6B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-RERE | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-REOR | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-REGO | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-REGR | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-REAQ | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-ORRE | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-OROR | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-ORGO | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-ORAQ | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-GORE | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-GOOR | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-GOGO | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-GOGR | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-GOAQ | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-GRRE | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-GROR | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-GRGO | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-GRGR | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-GRAQ | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-AQRE | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-AQOR | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-AQGO | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-AQGR | 20 (40 μL) | 200 μL |
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| EHMT2-ATF6B-20-AQAQ | 20 (40 μL) | 200 μL |
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ATF6B Gene Summary
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Name: Activating Transcription Factor 6 Beta
Chromosome: CHR6: 32083044 -32096017
Locus: 6p21.32
EHMT2 Gene Summary
This gene encodes a methyltransferase that methylates lysine residues of histone H3. Methylation of H3 at lysine 9 by this protein results in recruitment of additional epigenetic regulators and repression of transcription. This gene was initially thought to be two different genes, NG36 and G9a, adjacent to each other in the HLA locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: Euchromatic Histone Lysine Methyltransferase 2
Chromosome: CHR6_mcf_hap5: 3227409 -3245344
Locus: 6p21.33
Gene Diseases
The EHMT2 ATF6B Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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