EHMT1-GRIN1 Fusion FISH Probe
The EHMT1-GRIN1 Fusion FISH Probe is used to confirm a fusion of the EHMT1 and GRIN1 genes. The fusion of the EHMT1 and GRIN1 genes has been associated with Breast Invasive Carcinoma, and Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EHMT1-GRIN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-RERE | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-REOR | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-REGO | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-REGR | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-REAQ | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-ORRE | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-OROR | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-ORGO | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-GORE | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-GOOR | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-GOGO | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-GOGR | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-GRRE | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-GROR | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-GRGO | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-GRGR | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-AQRE | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-AQOR | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-AQGO | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-AQGR | 20 (40 μL) | 200 μL |
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| EHMT1-GRIN1-20-AQAQ | 20 (40 μL) | 200 μL |
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GRIN1 Gene Summary
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Gene Name: Glutamate Ionotropic Receptor NMDA Type Subunit 1
Chromosome: CHR9: 140033608 -140063214
Locus: 9q34.3
EHMT1 Gene Summary
The protein encoded by this gene is a histone methyltransferase that methylates the lysine-9 position of histone H3. This action marks the genomic region packaged with these methylated histones for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
Gene Name: Euchromatic Histone Lysine Methyltransferase 1
Chromosome: CHR9: 140513443 -140730578
Locus: 9q34.3
Gene Diseases
The EHMT1 GRIN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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