EHMT1-GFI1B Fusion FISH Probe
The EHMT1-GFI1B Fusion FISH Probe is used to confirm a fusion of the EHMT1 and GFI1B genes. The fusion of the EHMT1 and GFI1B genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EHMT1-GFI1B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-RERE | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-REOR | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-REGO | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-REGR | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-REAQ | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-ORRE | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-OROR | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-ORGO | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-ORAQ | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-GORE | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-GOOR | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-GOGO | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-GOGR | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-GOAQ | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-GRRE | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-GROR | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-GRGO | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-GRGR | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-GRAQ | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-AQRE | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-AQOR | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-AQGO | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-AQGR | 20 (40 μL) | 200 μL |
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| EHMT1-GFI1B-20-AQAQ | 20 (40 μL) | 200 μL |
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GFI1B Gene Summary
This gene encodes a zinc-finger containing transcriptional regulator that is primarily expressed in cells of hematopoietic lineage. The encoded protein complexes with numerous other transcriptional regulatory proteins including GATA-1, runt-related transcription factor 1 and histone deacetylases to control expression of genes involved in the development and maturation of erythrocytes and megakaryocytes. Mutations in this gene are the cause of the autosomal dominant platelet disorder, platelet-type bleeding disorder-17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Gene Name: Growth Factor Independent 1B Transcriptional Repressor
Chromosome: CHR9: 135854097 -135867084
Locus: 9q34.13
EHMT1 Gene Summary
The protein encoded by this gene is a histone methyltransferase that methylates the lysine-9 position of histone H3. This action marks the genomic region packaged with these methylated histones for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
Gene Name: Euchromatic Histone Lysine Methyltransferase 1
Chromosome: CHR9: 140513443 -140730578
Locus: 9q34.3
Gene Diseases
The EHMT1 GFI1B Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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