EGR1-PLAT Fusion FISH Probe
The EGR1-PLAT Fusion FISH Probe is used to confirm a fusion of the EGR1 and PLAT genes. The fusion of the EGR1 and PLAT genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EGR1-PLAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-RERE | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-REOR | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-REGO | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-REGR | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-REAQ | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-ORRE | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-OROR | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-ORGO | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-GORE | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-GOOR | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-GOGO | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-GOGR | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-GRRE | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-GROR | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-GRGO | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-GRGR | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-AQRE | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-AQOR | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-AQGO | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-AQGR | 20 (40 μL) | 200 μL |
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| EGR1-PLAT-20-AQAQ | 20 (40 μL) | 200 μL |
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EGR1 Gene Summary
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]
Gene Name: Early Growth Response 1
Chromosome: CHR5: 137801180 -137805004
Locus: 5q31.2
PLAT Gene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Plasminogen Activator, Tissue Type
Chromosome: CHR8: 42032235 -42065194
Locus: 8p11.21
Gene Diseases
The EGR1 PLAT Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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