EGLN2-PLD3 Fusion FISH Probe
The EGLN2-PLD3 Fusion FISH Probe is used to confirm a fusion of the EGLN2 and PLD3 genes. The fusion of the EGLN2 and PLD3 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EGLN2-PLD3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-RERE | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-REOR | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-REGO | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-REGR | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-REAQ | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-ORRE | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-OROR | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-ORGO | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-ORAQ | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-GORE | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-GOOR | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-GOGO | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-GOGR | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-GOAQ | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-GRRE | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-GROR | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-GRGO | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-GRGR | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-GRAQ | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-AQRE | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-AQOR | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-AQGO | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-AQGR | 20 (40 μL) | 200 μL |
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| EGLN2-PLD3-20-AQAQ | 20 (40 μL) | 200 μL |
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PLD3 Gene Summary
This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]
Gene Name: Phospholipase D Family Member 3
Chromosome: CHR19: 40854331 -40884390
Locus: 19q13.2
EGLN2 Gene Summary
The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene. [provided by RefSeq, Feb 2011]
Gene Name: Egl-9 Family Hypoxia Inducible Factor 2
Chromosome: CHR19: 41305047 -41314346
Locus: 19q13.2
Gene Diseases
The EGLN2 PLD3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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