EGFR-GRB10 Fusion FISH Probe
The EGFR-GRB10 Fusion FISH Probe is used to confirm a fusion of the EGFR and GRB10 genes. The fusion of the EGFR and GRB10 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EGFR-GRB10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-RERE | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-REOR | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-REGO | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-REGR | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-REAQ | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-ORRE | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-OROR | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-ORGO | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-ORAQ | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-GORE | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-GOOR | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-GOGO | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-GOGR | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-GOAQ | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-GRRE | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-GROR | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-GRGO | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-GRGR | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-GRAQ | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-AQRE | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-AQOR | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-AQGO | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-AQGR | 20 (40 μL) | 200 μL |
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| EGFR-GRB10-20-AQAQ | 20 (40 μL) | 200 μL |
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EGFR Gene Summary
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]
Gene Name: Epidermal Growth Factor Receptor
Chromosome: CHR7: 55086724 -55275031
Locus: 7p11.2
GRB10 Gene Summary
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
Gene Name: Growth Factor Receptor Bound Protein 10
Chromosome: CHR7: 50657759 -50861159
Locus: 7p12.1
Gene Diseases
The EGFR GRB10 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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