EFTUD2-DUSP3 Fusion FISH Probe
The EFTUD2-DUSP3 Fusion FISH Probe is used to confirm a fusion of the EFTUD2 and DUSP3 genes. The fusion of the EFTUD2 and DUSP3 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EFTUD2-DUSP3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-RERE | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-REOR | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-REGO | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-REGR | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-REAQ | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-ORRE | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-OROR | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-ORGO | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-ORAQ | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-GORE | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-GOOR | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-GOGO | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-GOGR | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-GOAQ | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-GRRE | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-GROR | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-GRGO | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-GRGR | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-GRAQ | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-AQRE | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-AQOR | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-AQGO | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-AQGR | 20 (40 μL) | 200 μL |
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| EFTUD2-DUSP3-20-AQAQ | 20 (40 μL) | 200 μL |
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DUSP3 Gene Summary
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]
Gene Name: Dual Specificity Phosphatase 3
Chromosome: CHR17: 41843488 -41856368
Locus: 17q21.31
EFTUD2 Gene Summary
This gene encodes a GTPase which is a component of the spliceosome complex which processes precursor mRNAs to produce mature mRNAs. Mutations in this gene are associated with mandibulofacial dysostosis with microcephaly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Name: Elongation Factor Tu GTP Binding Domain Containing 2
Chromosome: CHR17: 42927654 -42976993
Locus: 17q21.31
Gene Diseases
The EFTUD2 DUSP3 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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