EFNA5-MCC Fusion FISH Probe
The EFNA5-MCC Fusion FISH Probe is used to confirm a fusion of the EFNA5 and MCC genes. The fusion of the EFNA5 and MCC genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EFNA5-MCC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-RERE | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-REOR | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-REGO | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-REGR | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-REAQ | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-ORRE | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-OROR | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-ORGO | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-ORAQ | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-GORE | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-GOOR | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-GOGO | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-GOGR | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-GOAQ | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-GRRE | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-GROR | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-GRGO | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-GRGR | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-GRAQ | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-AQRE | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-AQOR | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-AQGO | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-AQGR | 20 (40 μL) | 200 μL |
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| EFNA5-MCC-20-AQAQ | 20 (40 μL) | 200 μL |
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EFNA5 Gene Summary
Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]
Gene Name: Ephrin A5
Chromosome: CHR5: 106712589 -107006596
Locus: 5q21.3
MCC Gene Summary
This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Mutated In Colorectal Cancers
Chromosome: CHR5: 112357795 -112824527
Locus: 5q22.2
Gene Diseases
The EFNA5 MCC Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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