EFNA3-HFE2 Fusion FISH Probe
The EFNA3-HFE2 Fusion FISH Probe is used to confirm a fusion of the EFNA3 and HFE2 genes. The fusion of the EFNA3 and HFE2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EFNA3-HFE2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-RERE | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-REOR | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-REGO | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-REGR | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-REAQ | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-ORRE | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-OROR | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-ORGO | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-ORAQ | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-GORE | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-GOOR | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-GOGO | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-GOGR | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-GOAQ | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-GRRE | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-GROR | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-GRGO | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-GRGR | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-GRAQ | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-AQRE | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-AQOR | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-AQGO | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-AQGR | 20 (40 μL) | 200 μL |
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| EFNA3-HFE2-20-AQAQ | 20 (40 μL) | 200 μL |
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EFNA3 Gene Summary
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. [provided by RefSeq, Jul 2008]
Gene Name: Ephrin A3
Chromosome: CHR1: 155051347 -155060014
Locus: 1q21.3
HFE2 Gene Summary
The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq, Oct 2015]
Gene Name: Hemochromatosis Type 2 (juvenile)
Chromosome: CHR1: 145413190 -145417545
Locus: 1q21.1
Gene Diseases
The EFNA3 HFE2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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