EFNA1-ADAM15 Fusion FISH Probe
The EFNA1-ADAM15 Fusion FISH Probe is used to confirm a fusion of the EFNA1 and ADAM15 genes. The fusion of the EFNA1 and ADAM15 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EFNA1-ADAM15-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-RERE | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-REOR | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-REGO | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-REGR | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-REAQ | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-ORRE | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-OROR | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-ORGO | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-ORAQ | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-GORE | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-GOOR | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-GOGO | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-GOGR | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-GOAQ | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-GRRE | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-GROR | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-GRGO | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-GRGR | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-GRAQ | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-AQRE | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-AQOR | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-AQGO | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-AQGR | 20 (40 μL) | 200 μL |
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| EFNA1-ADAM15-20-AQAQ | 20 (40 μL) | 200 μL |
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EFNA1 Gene Summary
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]
Gene Name: Ephrin A1
Chromosome: CHR1: 155100348 -155107386
Locus: 1q22
ADAM15 Gene Summary
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Name: ADAM Metallopeptidase Domain 15
Chromosome: CHR1: 155023761 -155035252
Locus: 1q21.3
Gene Diseases
The EFNA1 ADAM15 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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