EFCAB6-OSBP2 Fusion FISH Probe
The EFCAB6-OSBP2 Fusion FISH Probe is used to confirm a fusion of the EFCAB6 and OSBP2 genes. The fusion of the EFCAB6 and OSBP2 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EFCAB6-OSBP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-RERE | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-REOR | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-REGO | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-REGR | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-REAQ | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-ORRE | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-OROR | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-ORGO | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-GORE | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-GOOR | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-GOGO | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-GOGR | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-GRRE | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-GROR | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-GRGO | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-GRGR | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-AQRE | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-AQOR | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-AQGO | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-AQGR | 20 (40 μL) | 200 μL |
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| EFCAB6-OSBP2-20-AQAQ | 20 (40 μL) | 200 μL |
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OSBP2 Gene Summary
The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2013]
Gene Name: Oxysterol Binding Protein 2
Chromosome: CHR22: 31090792 -31303811
Locus: 22q12.2
EFCAB6 Gene Summary
This gene encodes a protein which directly binds the oncogene DJ-1 and androgen receptor to form a ternary complex in cells. This binding protein recruits histone-deacetylase complexes in order to repress transcription activity of androgen receptor. This protein may also play a role in spermatogenesis and fertilization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Name: EF-hand Calcium Binding Domain 6
Chromosome: CHR22: 43924623 -44208217
Locus: 22q13.2-q13.31
Gene Diseases
The EFCAB6 OSBP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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